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The project involves the development of methods based on scanning probe microscopy (SPM), mainly atomic force (AFM) but also scanning tunnelling microscopy (STM), for the study of the interaction between nanomaterials and biolological systems in the framework of the research project “Nanodiamond for selective and highly sensitive biosensors”. AFM will be used for the morphological characterization of the realized nanomaterials and in particular the nanodiamond layers. Moreover, methodologies will be ad hoc developed to study the covering with antigens of the obtained surfaces. To that aim, phase imaging and adhesion force microscopy (AdFM) will be used, based both on standard AFM mode and on torsional harmonics AFM (TH-AFM), using tips covered by suitable antibodies. AFM, atomic force acoustic microscopy (AFAM), TH-AFM will be used to characterize the adhesion of bacteria and the presence of nanomaterials in biological films
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