Study of the inhibitors of Thioredoxin Reductase from P. falciparum

The enzymes of the metabolic pathway of thioredoxin play a fundamental role in the physiology of all organisms, and are involved in the pathology of several diseases. Thioredoxin Reductase is essential for the survival and the virulence of the human parasite P. falciparum. The enzyme has been cloned and heterologously expressed in E.coli, and our research project includes its structural and functional characterization, with special reference to the effect of known or putative inhibitors. These will be characterized by steady state and rapid kinetic methods (if applicable) and crystallization of the enzyme inhibitor complex will be attempted with the aim of obtaining their 3D structure.

Research Fields

Biological sciences

Eligibility criteria

assessment of CV and qualifications and follow-up interview by the board of examiners

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Programme Description

Number of awards per year	1
Annual budget	22.946,04
Frequency of calls	1
International mobility required ?	no
Eligible destination country/ies for fellows	Italy
Eligibility of fellows: country/ies of residence	All
Eligibility of fellows: nationality/ies	All
Website of Fellowship Programme	https://server1.phys.uniroma1.it/physmg/ext/bandipub/main.php

Fellowship's Details

Career Stage	Early stage researcher or 0-4 yrs (Post graduate)
Research Profile	Not defined
Employment contract with full social security	no
Total amount per fellowship per year	19367
Currency	euro
Covers salary	yes
Covers travel and subsistence	no
Covers research costs	no
Maximum duration of fellowship	12