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http://www.unimib.it/link/news.jsp?8763694841602865420 Production and characterization of murine cell lines with sequence-specific genetic modification. The genetic modification will ensure the simultaneous expression of a combination of human genes that are protective against xenotransplant rejection. The genetically modified cell lines will be tested for the expression of the human genes, and the protection against pro-inflammatory stimuli will be stested in vitality and toxicity assays after exposure of cells to TNF-a or IL1-b. the molecular mechanism of the protection mediated by the overexpression of the human genes will be also evaluated.
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