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Characterization of epigenome deregulation in leukemia and identification of antileukemic epi- compounds through screening techniques. Epigenetic alterations have a proven role in human leukemias and, thus ,the characterization of the events of histone modification with HTS techniques is of fundamental importance for the identification of epi-biomarkers in leukemias. The identification of compounds able to revert these changes is a fundamental step anticancer approach.
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