Study of the effects of isolated domains of aminoacyl tRNA syntethases on human cells carrying mt tRNA mutations.

The overall objective of this project is to demonstrate the ability of isolated domains from mitochondrial (mt) aminoacyl-tRNA synthetases to rescue the mitochondrial defect caused by point mutations in mt tRNA genes in human cells. In particular, we will evaluate the effect of the isolated carboxy-terminal domain of human mt leucyl-tRNA synthetase and small fragments derived from it, in cybrid cells with the m.3243A>G mutation in tRNALeu(UUR), causing the severe Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes (MELAS) syndrome.

Research Fields

Medical sciences - Medicine

Eligibility criteria

Bachelor in Science

Bachelor in Science

PhD degree

Peer reviewed publications related to topic of the project

Selection process

Selection of candidates will be based on the requirements as of the announcement of selection and on an interview on the following topic: Therapeutic effect of specific compounds on transmitocondrial cybrids bearing mt tRNA pathogenic mutations . Personal experience.

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Programme Description

Number of awards per year	1
Annual budget	19.367,00 €
Frequency of calls	mensile
International mobility required ?	no
Eligible destination country/ies for fellows	Italy
Eligibility of fellows: country/ies of residence	All
Eligibility of fellows: nationality/ies	All
Website of Fellowship Programme	http://www2.uniroma1.it/organizzazione/amministrazione/ripartizionepersonale/concorsi/assegni/default.php

Fellowship's Details

Career Stage	Early stage researcher or 0-4 yrs (Post graduate)
Research Profile	Not defined
Employment contract with full social security	no
Total amount per fellowship per year	19367
Currency	euro
Covers salary	yes
Covers travel and subsistence	no
Covers research costs	no