Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (22/01/2013 03.05)

Study of the effects of isolated domains of aminoacyl tRNA syntethases on human cells carrying mt tRNA mutations.

Please note that the job is no longer active!

The overall objective of this project is to demonstrate the ability of isolated domains from mitochondrial (mt) aminoacyl-tRNA synthetases to rescue the mitochondrial defect caused by point mutations in mt tRNA genes in human cells. In particular, we will evaluate the effect of the isolated carboxy-terminal domain of human mt leucyl-tRNA synthetase and small fragments derived from it, in cybrid cells with the m.3243A>G mutation in tRNALeu(UUR), causing the severe Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-like episodes (MELAS) syndrome.

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Research Fields

Medical sciences - Medicine

Eligibility criteria

Bachelor in Science

Bachelor in Science

PhD degree

Peer reviewed publications related to topic of the project

Selection process

Selection of candidates will be based on the requirements as of the announcement of selection and on an interview on the following topic: Therapeutic effect of specific compounds on transmitocondrial cybrids bearing mt tRNA pathogenic mutations . Personal experience.

Programme Description
Number of awards per year1
Annual budget19.367,00 €
Frequency of callsmensile
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Employment contract with full social securityno
Total amount per fellowship per year19367
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
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Application deadline


Other fellowship details


Funding organisation / Contacts
Università di Roma Sapienza

Public research
Roma - Italy