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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (11/01/2013 03.36)

NMR characterization of the structural basis for the interaction between CRY and INAD in D. melanogaster

Please note that the job is no longer active!

dCRY mediates light synchronization of the fly circadian master clock. The C-terminus of dCRY plays an important role in modulating light sensitivity and activity of the protein and it harbours several protein-protein interaction motifs (Linear Motifs: LMs). Co-immunoprecipitation assays and mass spectrometry analysis have revealed that dCRY is bound to NINAC, an element of the fly's visual cascade assembled in a multiprotein signalling complex organized by INAD, a scaffolding protein with 5 structural PDZ domains. Preliminary results demonstrate that dCRY is recognised by the region of INAD which comprises the PDZ2 and PDZ3 domains and includes a predicted Calmodulin-binding motif. Aim of this research program is the NMR characterization of the interaction between dCRY and INAD. To this purpose, we will use NMR chemical shift mapping and 15N relaxation measurements to study the interaction of the aforementioned INAD fragment with suitable LM-containing peptides derived from dCRY.

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Research Fields

Biological sciences

Eligibility criteria

Comparative assessment and interview


Programme Description
Number of awards per year1
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programmehttp://protocollo.unipd.it/albo/viewer?view=files/03891410-000-allegato 0.pdf
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfileNot defined
Employment contract with full social securityyes
Total amount per fellowship per year19367
Currencyeuro
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
Maximum duration of fellowship12
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Application deadline

24/01/2013

Other fellowship details
Fellowship ID

45667

Funding organisation / Contacts
Università degli Studi di Padova - Dipartimento di Biologia

Public research
Padova - Italy
http://www.biologia.unipd.it/
E-mails
direbiol2@bio.unipd.itPhones
0039 049 8276235

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