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Specific chromatin modifications and multiprotein complexes mark sites of DNA damage and are involved in the correct execution of DNA repair. Enzymes with a role in genome integrity and stability have been identified. However, the cross-talk between DNA repair/replication mechanisms and chromatin organization is still poorly characterized. Even less understood is the effect on gene expression programs including the link with alternative splicing. This project aims at characterizing the effect on chromatin organization and gene expression programs resulting from mutation in a re plicative enzyme (DNA ligase I) or in the XPD, XPB e TTD-A subunits of the general transcription factor TFIIH. The applicant should have well-proven experience in Chromatin immunoprecipitation, real time PCR, and cell biology (cell culture, transfection, immunofluorescence)
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