Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (28/12/2012 03.09)

Targeted drug delivery systems in oncology: analysis of the biocompatibility and efficacy of the nanocomposite hybrid hydrogels loaded with antineoplastic drugs

Please note that the job is no longer active!

Biomedical devices have been introduced in several medical fields. Aim of the proposal is to investigate, in bone metastatic tumor treatment, the efficacy of nanocomposite hybrid hydrogels loaded with antineoplastic drugs. The proposal will be organized as following:

1) analysis of the biocompatibility of the nanocomposite hybrid hydrogels. Effects on cell toxicity, growth and differentiation will be carried out at short and long experimental times;

2) preclinical investigation of the in vitro and in vivo efficacy of the devices as a delivery systems for targeted release of antineoplastic/antiangiogenic drugs.

The cytotoxic/molecular effects of both the drugs and the hydrogel degradation products will be analyzed using human prostate and breast cancer cell lines, examples of bone metastasis, and human endothelial cells. The preclinical therapeutical efficacy of drugs released from the devices will be tested in vivo in animal models of subcutaneous-engrafted tumors in mice

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Research Fields

Biological sciences

Programme Description
Number of awards per year1
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
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Funding organisation / Contacts
Università degli Studi di Siena

Public research
Siena - Italy