Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (28/12/2012 03.09)

A study on the mechanism by which oleuropein aglycone activates autophagy in cultured cells and in C. elegans

Please note that the job is no longer active!

Oleuropein aglycone (OLE) is a polyphenol typical of the extra virgin olive oil to which, in addition to the anti-oxidant power, several other beneficial properties have been attributed; in our laboratory, we have shown that OLE inhibits the growth of toxic aggregates in vitro by Abeta and amylin, involved in the Alzheimer's and type 2 diabetes, respectively.. We have also observed that OLE stimulates autophagy, a key cellular process which often is activated in the course of amyloid pathologies as a response to protein misfolding but without going to completion due to lysosomes overload thus contributing to disease progression. Accordingly, molecules able to restore the functional course of autophagy are good candidates for prevention and treatment of these diseases.

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Research Fields

Biological sciences - Biology

Eligibility criteria

Graduate V.O. in Biology or Biotechnology or Pharmaceutical Chemistry and Technology or corresponding degrees Specialist / Magistral NO

Selection process

the competition will be carried aiu by an avalutation of titles and examination, by means of an interview

Programme Description
Number of awards per year1
Annual budget19367
Frequency of calls1
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
Employment contract with full social securityyes
Total amount per fellowship per year22946.28
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
Maximum duration of fellowship12
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Other fellowship details


Funding organisation / Contacts

Public research
Firenze - Italy