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Emerging literature data indicate as cell commitment and differentiation imply genome wide reprogramming by means of multistep epigenetic modifications. This project focus on the study of the epigenetic reprogramming underlying the alternative resident liver stem cells (RLSCs) epithelial or mesenchymal differentiation choices. In particular it plans to better understand the epigenetic mechanisms driving the alternative stem cell fate decisions and, in the long term, to design new therapeutic strategies, effective and possibly combinatorial, to negatively control the mesenchymal/ stellate/ myofibroblast differentiation of the stem compartment in pathological conditions.
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Biological sciences - Biology
Vote of Full Degree; Publications ; Ph.D. Diplomas and certificates of attendance of post-graduate courses; Other activities related to the research activity. Interview on the research topic
ranking obtained by the sum of the scores of titles and the score obtained in the interview
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