Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (06/12/2012 02.37)

*Structural characterization of Glutaminyl-Cyclase and of protein-small molucules adduct through NMR

Please note that the job is no longer active!

QPCT is a metalloenzyme responsible for the conversion of the N-terminal glutaminyl residues of peptides and proteins into pyroglutamic acid with the liberation of ammonia. This cyclization reaction is a common post-translational event required in the maturation of numerous bioactive neuropeptides, hormones, and cytokines. It has been shown that QPCT catalyzes the formation of pyroglutamate-modified Aβ peptides that, because of their abundance, high aggregation propensity, resistance to proteolysis, and neurotoxicity, play an important role in the pathology of Alzheimer disease. Pharmacological inhibition of QPCT results in reductions of pyroglutamate-modified Aβ peptides and Alzheimer's disease-like pathology.

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Research Fields

Chemistry - Inorganic chemistry

Programme Description
Number of awards per year1
Annual budget22946
Frequency of calls12 mesi
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Employment contract with full social securityyes
Total amount per fellowship per year22946
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
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Funding organisation / Contacts
Università di Firenze- Dipartimento di Chimica

Public research
Sesto Fiorentino - Italy