'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Researchers.
Please note that the job is no longer active!
Dendritic cells are antigen presenting cells involved in innate and adaptative immunity. There is a great interest on their pathogenetic role on inflammatory and immunological-related diseases, such as multiple sclerosis (MS) as well as atherosclerosis. It has been demonstrated that DC are involved in epitope spreading, necessary event during progression of MS; moreover it is known that DC number increases in atherosclerotic lesions and in the symptomatic lesions. Poly [ADP-ribose] polymerase 1 (PARP-1) is a key nuclear enzyme in the regulation of gene expression which is expressed in DC during their differentiation. In Apo-/- mice model of atherosclerosis PARP-1 is associated to inflammatory responses. The aim of this project is to study in vitro pharmacological PARP-1 modulation on DC differentiation, phenotype and function
Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!
To better plan and organise their stay in a foreign European country, researchers and their families can also benefit of the free and personalised assistance offered by the EURAXESS Services Centres, a network of more than 200 centres located in 40 different European countries.