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Aim of the proposal is the evaluation of different antineoplastic drugs (even mixed) adsorption on different types of nanocomposite hydrogels, the quali-quantitatively evaluation of the interation forces, the drugs chemical - physical stability in the nanocomposite hydrogel system and the kinetics of drugs or mixture release from the system by external magnetic fields application.
The proposal will be organized as following:
1- composite hydrogels loading with antineoplastic drugs
2- development of methods for the characterization of nanocomposite hydrogels-drugs system
3- development of methods for the release analysis by external magnetic fields application
4- evaluation of drug stability during and after the release
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