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In Ciona intestinalis, as in other organisms, different immune molecules contribute to the mucosal defense of the gut where a fine-tuning regulates the relationship between symbiotic and pathogenic bacteria. Among these molecules, Variable-region Containing Chitin Binding Proteins (VCBPs), identified and sequenced in our laboratory, are candidate to play a pivotal role in this process. The involvement of these molecules in the regulation of gut homeostasis is a relevant task that can be pursued by combining a biochemical and cell biological approach for the purification and characterization of VCBP-B. It is mandatory the choice of the most appropriate purification procedures together with biological assays aimed at the identification of functional activities such as bacteria binding, opsonization, phagocytosis, and chemotaxis. Study of intestinal dysbiosis in mammals could greatly benefit from the results obtained in our system
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To participate in the competition, candidates must possess the following qualifications: Degree in Biological Sciences, Chemistry, or related disciplines. Skills in biochemistry and cell biology techniques are required. Experience in the field of invertebrate and tunicate immunity, is preferred. These requirements must be fulfilled on the date of expiry of the deadline for submission of applications for admission to the selection. The exclusion from the selection, for lack of necessary qualifications, shall be notified to the candidates by a motivated decree.
Competition based on qualifications and interview. The assessment of the candidates will be conducted by a special jury, which will examine the qualifications and the performance of an interview aimed at ascertaining the candidate's professional expertise in scientific, as well as his attitude to carry out specific research subject of the application.
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