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Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (22/11/2012 02.53)

A combined biochemical and cell biology apporach to improve the pharmacological treatment of PH1: from pyridoxine derivatives to proteostasis regulators.

Please note that the job is no longer active!

The mechanisms by which B6 reduces the synthesis and excretion of urinary oxalate are not well known. Our preliminary studies suggest that vitamin B6 can affect AGT in many ways including increasing its activity, stability and modyfying where it is targeted within the cell. A better knowledge og how vitamin B6 works in PH1 would allow us to design modified forms of vitamin B6, which would be more effective in helping AGT attain a functional structure and enhance the specific effect of vitamin B6 by combining it with small molecules known to have a non-specific effect on protein folding. This project would allow us to define criteria correlating the mutation, type of enzyme dysfunction and B6-responsiveness. Such work would be a pre-requisite for a patient-tailored therapeutic management of PH1 but could also lead to novel strategies in terms of treatment.

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Research Fields

Biological sciences

Selection process

The competition will be carried out by an evaluation of titles and examination by means of an interview.


Programme Description
Number of awards per year1
Annual budget22950
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programmehttp://www.univr.it/documenti/Albo/allegatialbo/allegatialbo503743.pdf
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfileNot defined
Employment contract with full social securityyes
Total amount per fellowship per year19367
Currencyeuro
Covers salaryyes
Covers travel and subsistenceno
Covers research costsno
Maximum duration of fellowship12
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Application deadline

07/12/2012

Other fellowship details
Fellowship ID

42798

Funding organisation / Contacts
Università degli Studi di Verona - Dipartimento di Scienze della Vita e della Riproduzione

Public research
Verona - Italy
http://www.univr.it/jsp/default.jsp
E-mails
assegni.ricerca@univr.itPhones
+ 39 (0) 45 8028204

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