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Aim of the research project is the identification of the molecular mechanisms and signalling systems implicated in platelet activation in the setting of cardiovascular disease and clinical conditions characterized by increased risk for cardio and cerebrovascular events. Focus will be on soluble platelet agonists and their effects on platelet function, platelet adhesion in different experimental models and the interaction between platelets, endothelial cells and leukocytes. Implications in drug monitoring and the diagnosis of cardiovascular diseases will be explored.
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