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Environmental toxic pollutants (ETPs) are food contaminants associated with mutagenic and/or carcinogenic activity. Epidemiologic studies have demonstrated that one third of tumours are food related. Among ETPs, the persistent organic pollutants (POPs) are of great interest because of their wide spread into water, soil and food chain causing damage to environment and human health even very far from their emission source. International agreement (Stockholm convention, 2004) has been adopted in order to reduce their emission. Mass spectrometry is the structural and analytical approach to indentify POPs in food matrices and to study both in vitro and in vivo their mechanism of toxicity in order to identify markers of exposure. The aim of this project is to set up a differential proteomic approach using selected cell lines for the identification of proteins expressed after their exposition to POPs of interest and the evaluation of these proteins as exposure biomoarkers
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