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The main goal of this project is to evaluate the possible anti-neuropathic effect of human mesenchymal stem cell transplantation in the lateral ventricle of mouse. In particular, this study is aimed at investigating whether or not cell transplantation is able to inhibit allodynia and hyperalgesia, and normalize specific bio-molecular, neurochemical, functional and morphological changes in the spinal cord (L4-L6) and pre-frontal cortex in a widely used model of neuropathic pain (Spared Nerve Injury, SNI). Moreover, it will be evaluated the role of glial and microglial cells, and in particular the neuron-glia cross-link, in the pathogenesis of neuropathic pain. The novelty of this study is the transplantation of human mesenchymal stem cells (hMSCs) directly in the lateral ventricle of mice.
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