Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (10/11/2012 02.26)

Involvement of chemookines in the moelcular mechanism of the mesenchymal stem cells: morphofunctional and biomolecular evaluation in a murine model of peripheral

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The main goal of this project is to evaluate the possible anti-neuropathic effect of human mesenchymal stem cell transplantation in the lateral ventricle of mouse. In particular, this study is aimed at investigating whether or not cell transplantation is able to inhibit allodynia and hyperalgesia, and normalize specific bio-molecular, neurochemical, functional and morphological changes in the spinal cord (L4-L6) and pre-frontal cortex in a widely used model of neuropathic pain (Spared Nerve Injury, SNI). Moreover, it will be evaluated the role of glial and microglial cells, and in particular the neuron-glia cross-link, in the pathogenesis of neuropathic pain. The novelty of this study is the transplantation of human mesenchymal stem cells (hMSCs) directly in the lateral ventricle of mice.

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Research Fields

Biological sciences

Programme Description
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Total amount per fellowship per year19367
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Funding organisation / Contacts
Seconda Università degli Studi di Napoli

Public research
Caserta - Italy