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In recent years many studies have underlined the important role of the neural networks connecting the anterior part of the insula with the orbito-medial and orbito-lateral regions of the frontal lobes, particularly in the right hemisphere, for emotion regulation. In patients with generalized anxiety disorders it is possible that these networks are altered by hyperactivity of the limbic structures (e.g., the amygdala). The different forms of generalized anxiety disorder might be related to different types of perturbation of these neural networks; in obsessive-compulsive disorders an inhibitory modulation might prevail, whereas somatophorm and hypochondriac disorders might be correlated to an imbalance of these neural networks.
To verify these hypotheses a study of functional and structural connectivity will be performed in 15 patients with obsessive-compulsive disorder and in 15 patients with hypo
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