Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (10/11/2012 02.25)

Alternative splicing as a tool to develop anti-angiogenic approaches to control cancer growth

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Alternative splicing is the process by which a single primary transcript (pre-mRNA) can be spliced in more than one pattern to generate multiple, distinct mature mRNAs leading to expression of protein isoforms with different structural and functional properties. AS provides a versatile mechanism to regulate many biological processes and to respond to physiological stimuli.

Recently, increasing evidences indicate the altered AS profiles of critical genes may impact on all the major aspects of cancer cell biology such as proliferation, differentiation, cell death, motility and invasion supporting a causative role of altered AS in cancer.

The long-term goal of our research is to define the role of alternative splicing (AS) in regulating tumor angiogenesis and discover novel AS isoforms expressed selectively on tumor endothelial cells in order to develop anti-angiogenic approaches to control cancer growth

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Research Fields

Biological sciences

Programme Description
Number of awards per year1
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
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Funding organisation / Contacts
Consiglio Nazionale delle Ricerche

Public research
Pavia - Italy
0382 546324