Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (10/11/2012 02.25)

Role of Hemoglobin B (HBB) in breast cancer: regulation of oxidative stress response and metastasis organotropism

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In the clinical practice bone metastatic breast cancer (BrCa) patients could be distinguished in 2 groups: patients with bone only metastases (BO) and patients with bone and visceral metastases (B+V), the latter having a poor clinical outcome. We performed a whole genome microarray analysis on bone metastases samples from these 2 groups of patients, unveiling a cluster of genes that were modulated in bone metastasis samples from B+V patients vs. bone metastases from BO patients. Among them we found Hemoglobin-beta(HBB), one of the most regulated genes. Moreover, immunohistochemistry performed on BrCa samples showed that tumor cells express HBB, and its expression increased in tumor cells that were able to colonize multiple sites other than bone. Therefore, the aim of the project is to investigate a potential role of HBB in BrCa and, as suggested by our preliminary data, whether HBB expression is involved in the ability of tumor cells to give rise to multiple metastases.

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Research Fields

Biological sciences

Programme Description
International mobility required ?no
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageExperienced researcher or 4-10 yrs (Post-Doc)
Research ProfilesNot defined
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Funding organisation / Contacts
Università degli Studi dell'Aquila

Public research
L'Aquila - Italy