Fellowship & Grant details

Fellowship posted by Italian Ministry of Education, University and Research (04/10/2012 02.51)

Functional interaction between inflammatory pathways and estrogen receptors signaling in breast cancer cells.

Please note that the job is no longer active!

Goal of this project is to elucidate the molecular determinants of the regulatory cross-talk that inflammatory pathways exert on steroid hormone genomic regulation. Tab2 is a component of the inflammatory pathway, and modulate response to various Transcription Factors by altering the coactivator/corepressor ratio at target genes, by displacing corepressor NCoR from transcriptional hubs. We reported that Tab2 interacts directly with Estrogen Receptor alpha and that constitutive activation of Tab2 confers Tamoxifen resistance to breast cancer cells by reversing the transcriptional response to many ERalpha-dependent genes (Cutrupi et al., 2012). In this project, we will 1) finely map the interaction of Tab2 with ERalpha and NCoR; 2) identify the mechanism of Tab2 activation and the proteins involved; 3) clarify the role of Tab2 in the genomic action of ERalpha in absence or presence of hormone, through genome wide transcription and chromatin occupancy studies.

Please note that the full description may be available in the national language since some job boards have their own publication policy. Thank you for your understanding!

Research Fields

Biological sciences

Other costs


Eligibility criteria

The call and how to apply are available at the following address:

Selection process

qualifications and interview (in Turin)

Programme Description
Number of awards per year1
Eligible destination country/ies for fellowsItaly
Eligibility of fellows: country/ies of residenceAll
Eligibility of fellows: nationality/iesAll
Website of Fellowship Programme
Fellowship's Details
Career StageEarly stage researcher or 0-4 yrs (Post graduate)
Research ProfilesNot defined
Employment contract with full social securityyes
Total amount per fellowship per year19367
Covers salaryyes
Covers travel and subsistenceyes
Covers research costsyes
Maximum duration of fellowship12
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Application deadline


Other fellowship details


Funding organisation / Contacts
Universita' degli Studi di Torino

Public research
Turin - Italy