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Cancer cachexia is a multifactorial syndrome characterized by loss of muscle and adipose tissue that negatively affects both patient quality of life and their tolerance to antineoplastic therapies. While a tissue hypercatabolic response is widely recognized to contribute to the pathogenesis of this syndrome, little is known about the involvement of impaired myogenesis. In this regards, previous results demonstrated that muscle “stem-like” quiescent (satellite) cells accumulate in the skeletal muscle of cachectic tumor-bearing animals (Penna et al., 2010). Aim of the present project is to assess if, in addition to satellite cells, also pericyte-like cells of mesodermic origin (mesoangioblasts) can be recruited to the cachectic muscle. In particular, the study will define the possibility to stress satellite cells and/or mesoangioblast activation and differentiation in order to improve muscle atrophy in experimental cancer cachexia. References: Penna F. et al., PLoS One, 5:e13604, 2010.
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