Why is it important
for life?
The endocrine system controls growth and development during
childhood, regulation of bodily functions in adulthood, and
the reproductive process.
The endocrine system is important for the control and regulation
of all the major functions and processes of the body:
- Energy control
- Reproduction
- Immunity
- Behaviour (e.g. fight or flight response)
- Growth and development
Hormones interact to maintain the above functions and help
to regulate our responses to disease, our ability to reproduce
and even influence our relationships and behaviour (such as
mother:child bonding).
As can be seen, many of the hormones act on tissues and organs
at several sites throughout the body. The target cells in these
tissues or organs contain specialised structures (receptors)
to which only a specific hormone can bind. The response that
occurs in the cell will depend on the receptor and cell type,
and the effects of other hormones to which that cell may also
be exposed. Also, a hormone that stimulates the activity of
one cell type may suppress that of a different cell type.
A similar, but not identical, endocrine system to that of humans
is found in nearly all vertebrates including other mammals,
fish, amphibians, reptiles and birds, although the precise structures
and roles of the various organs and hormones differ between
different groups, particularly in relation to the different
life cycle and development stages in different species. Invertebrates
such as molluscs, crustacea and insects also have endocrine
systems that control a similar range of body functions although
these have evolved along markedly different lines to those of
vertebrates.
The main glands and hormones of mammals are:
| Gland |
Hormones |
Target organs |
Main actions |
| Hypothalamus (specialised
region of the brain) |
Releasing or inhibiting hormones (e.g.
growth hormone releasing hormone (GHRH), somatostatin, corticotropin
releasing hormone (CRH), arginine vasopressin (AVP), gonadotropin
releasing hormone (GnRH) & thyrotropin releasing hormone
(TRH) |
Anterior pituitary |
Controls production/release of other hormones |
| Antidiuretic hormone (ADH) |
Kidney |
Controls water loss |
| Oxytocin (OT) -released via the posterior
pituitary (neurohypothysis) |
Uterus, Mammary glands |
|
| Anterior pituitary [adenohypophysis] |
Luteinizing hormone (LH) |
Gonads |
Control of ovarian oestrus
cycle & Leydig cells in testis
Control of ovarian oestrus cycle & Sertoli cells in
testis
Promotes milk production |
| Follicle stimulating hormone (FSH) |
Gonads |
| Prolactin |
Breast |
Thyroid stimulating hormone (TSH)
|
Thyroid glands |
Stimulates T4 production/release
Affects growth and metabolism |
| Growth hormone (GH) |
Generalised |
| Adrenocorticotropic hormone (ACTH) |
Adrenal glands |
Stimulates adrenal cortex |
| Thyroid |
Thyroxine (T4) [active form is tri-iodothyronine
T3] |
Many tissues |
Control of general metabolic rate, also
important for development and reproductive functions |
| Adrenal [suprarenal] cortex |
Glucocorticoids (e.g. cortisol & corticosterone |
Many tissues |
Diverse effects on inflammation and protein
synthesis |
| Mineralocorticoids (e.g. aldosterone) |
Many tissues |
Salt balance |
| Adrenal [suprarenal] medulla |
Adrenaline (Epinephrine) |
Many tissues |
Glycogenolysis, lipid mobilisation, smooth
muscle contraction, cardiac function |
| Noradrenaline (Norepinephrine) |
Many tissues |
Lipid mobilisation, arteriole contraction |
| Pancreas |
Insulin |
Many tissues including liver, adipose
tissue & muscle |
Facilitates utilisation of glucose by
cells & prevents excessive glycogen breakdown in liver
& muscle |
| Glucagon |
Many tissues including liver, adipose
tissue & muscle |
Prevents hypoglycaemia through action
on carbohydrate, fat & protein metabolism |
| Gonads |
Sex steroids (e.g. oestradiol, testosterone,
progesterone) |
Brain, gonads, accessory sex organs |
Sexual development & maintainance
of reproductive function and behaviour |
|