VOC Solvents Directive

Title: Aqueous Cleaning and Solvent Substitution
(protected by copyright, see content summary)

Author: George Verghese

Year : 2003

Main activities covered : 20

Content summary

This journal article discusses cleaning processes in chemical synthesis active pharmaceutical ingredients (API) manufacturing. An overview of advantages and disadvantages for both organic-based and aqueous-based solvents is also presented. The paper also expands on further issues to be considered in solvent substitution e.g. selecting the right chemistry and equipment design. It presents a case study pharmaceutical API company which applied aqueous cleaning procedures to reduce solvent use.
Please note that this article, published in the Pharmaceutical Technology Journal – 2003, 27, 10, 116-130, is under copyright and must be purchased (for example, via the British Library).

Title: Solvent Stewardship Award case studies (~1575 KB)

Author: ESIG

Year : 1999 - 2001

Main activities covered : 1, 3, 7, 8, 14, 17, 20

Content summary

Brief case studies to share best practise in solvent use.

Title: AEA/CS/16419033/REMA-09. Interim report on work carried out within the VOC programme during 1993/94 financial year. Annex K Final report on ChenInform on emissions from the pharmaceuticals sector (~ 123KB)

Author: AEA Technology

Year : 1994

Main activities covered : 20

Content summary

This report investigates VOC emissions in the pharmaceutical sector.