Commission Regulation (EU) No 234/2011 of 10 March 2011 implementing Regulation (EC) No 1331/2008 of the European Parliament and of the Council establishing a common authorisation procedure for food additives, food enzymes and food flavourings.
Paragraph 7 of the Commission Regulation requires that toxicological tests should be carried out in compliance with principles of good laboratory practice.
Article 5(7) on the general provisions on data for risk assessment requires that toxicological studies shall be conducted in facilities which comply with principles of good laboratory practice.
The EU receiving authority for Commission Regulation (EU) No 234/2011 is the European Food and Safety Authority (EFSA).
Further information on food additives can be found on the website of the European Commission's Directorate General for Health and Consumers (DG SANCO).