Platform Communication & Dissemination
Identification, dissemination and implementation of best practice
in the 3Rs
market place for 3Rs - connecting those who know and those who
need to know
The "market place" concept emerged at the
EPAA Dissemination Workshop (in November 2009) and as a
result of an in depth survey of information needs conducted
by The Center. The objective is to "trade" ideas, knowledge
and information on safety assessment of products using non-animal
methods where EPAA could play the role of a honest broker. The
gaps identified that EPAA would strive to fill in include:
- Available test methods, their domain of applicability,
limitations and potential for cross-sector application;
- Methods in development stage;
- Gaps in knowledge, or which endpoints still miss non-animal
- Attracting scientists from areas that are not necessarily
directly connected with regulatory testing or the 3Rs;
- Providing platform for dialogue with regulatory authorities
to facilitate acceptance of alternative approaches in a regulated
As there is no tool or format that would be suitable to all
audiences and needs, EPAA would make available to interested
parties a variety of tools with one objective in mind: getting
the right contents in adequate format to the target audiences.
The "market place concept applies to all EPAA activities under
all Platforms. The EPAA has now a number of "open stands" in
the "market place", like the thematic reviews, 3Rs awards, post-validation
workshops, data base of in house methods. Use of new web technologies
and social sites would be considered in collaboration with other
stakeholders and interested parties.
reviews - reproductive toxicity
The aim of the thematic reviews is to provide regulators, industry
and other parties, with concise, comprehensive and peer-reviewed
information on existing alternative methods and strategies in
use for safety testing, on their potential and limitations.
- The thematic review of 3Rs (Replacement, Reduction, Refinement)
opportunities in the field of Reproductive
Toxicity provides an overall picture
of the state-of-the-art of 3Rs approaches in use at all stages
of development (research, validation or regulatory acceptance).
These are particularly relevant where regulatory requirements
mandate the application of the 3Rs, such as during project
authorization procedures required by Directive
2010/63/EU on the protection of animals used for scientific
purposes, for the implementation of the Cosmetics Directive
(Directive 2003/15/EC) as well as in the context of REACH.
In addition to the comprehensive review of published information
covering all 3Rs, this project gains a particular added value
by conducting specific surveys on their current use in industry.
- The review provides updated ready-to-use
information in peer-reviewed
data sheets with predetermined criteria for data content as
developed for ECVAM’s DataBase service on ALternative Methods
(DB-ALM) that ensures the quality of the information provided.
The outcome will supply regulators, users in industry and
academia, in addition to the already published extensive reviews
of publicly available scientific information resources also
with the results of the surveys performed to assess the real
use of each method in the various industries. The review is
disseminated via the DB-ALM benefiting from its retrieval
and search facilities. The first and principal part of the
review was completed in 2011 and provides 39 Method
descriptions and related information
with an overall Topic
Summary data sheet. This was based on
an extensive data retrieval activity (more than 3200 data
base search results were initially analysed covering all the
3Rs) and already complemented with the results of the first
survey carried out in industry on the use of in vitro methods.
In Q1 2012 the 2nd survey within industry is undertaken to
cover the other 2Rs (Reduction and Refinement) in vivo methods
used either as stand-alone methods or as part of Integrated
Testing Strategies (ITS). This last part of the project was completed in 2012.
awards - attracting new sciences/new scientists to 3Rs research
- The aim of the Science
award is to support the development and regulatory
acceptance of 3Rs alternative methods.
- The aim of the Communication
prize is to raise help translating technological
progress into non technical language to increase understanding
of the product innovation process, regulatory requirements
and to inform the public and political debate about product
safety and opportunities and limitation of alternative test
2011 conference Award session
the cross-fertilization potential of EPAA inventories of methods
The EPAA data bases have been created as a pilot project to
share and evaluate cross-sector reapplication of certain 3Rs
approaches developed and validated in house. Currently, EPAA
experts are evaluating the data bases of 3Rs methods used in
house and ongoing 3Rs-related research programmes, to identify
further opportunities for cross-sector application of specific
3R strategies as well as to identify research gaps.
data base – public summary report
data base – public summary report
Financial Support and
Endorsement of third party activities
EPAA is able to partner with other organisations by providing
the financial support and endorsement of events (workshops,
symposia, conferences etc.), or communication tools (such as
journals, books, videos etc.) that seek to further the
reduction, refinement and replacement (3Rs) of animal use
in regulatory testing, and within the limits of budgetary constraints.
for Financial Support and Endorsement.
The aim of this open stand is to support creation of tools
that serve the purpose to promote good practice and help implementation
of EU legislation.
- In 2009 EPAA co-sponsored publication of the FELASA guide
to the revised Appendix A to the Council of Europe Convention
ETS123 on the accommodation and care of laboratory animals.
- Further initiatives could be considered upon request from
On the accommodation and care of animals used for experimental
and other scientific purposes
(Based on the revised Appendix A of the European Convention
ETS 123) (FELASA)